Table 3.
Overall association between relative telomere length measured in peripheral blood and risk of skin cancer.
| Telomere length | Telomere length, Mean (SD) | Cases n (%) | Controls n (%) | Model 1 OR1 (95% CI) | Model 2 OR2 (95% CI) |
|---|---|---|---|---|---|
| Melanoma | |||||
| First tertile (≤0.67) | 0.46 (0.13) | 19 (9.6%) | 122 (32.8%) | 1.00 (reference) | 1.00 (reference) |
| Second tertile (0.68-1.11) | 0.90 (0.13) | 72 (36.4%) | 125 (33.6%) | 3.55 (2.01 - 6.29) | 3.26 (1.74-6.14) |
| Third tertile (≥1.12) | 1.77 (1.64) | 107 (54.0%) | 125 (33.6%) | 4.54 (2.60 – 7.94) | 3.75 (2.02-6.94) |
| Ptrend | <0.0001 | <0.0001 | |||
| Squamous cell carcinoma | |||||
| First tertile (≤0.67) | 0.42 (0.14) | 97 (71.3%) | 122 (32.8%) | 1.00 (reference) | 1.00 (reference) |
| Second tertile (0.68-1.11) | 0.87 (0.13) | 32 (23.5%) | 125 (33.6%) | 0.29 (0.17 - 0.50) | 0.26 (0.14-0.48) |
| Third tertile (≥1.12) | 3.44 (12.0) | 7 (5.2%) | 125 (33.6%) | 0.04 (0.02 - 0.09) | 0.01 (0.00-0.05) |
| Ptrend | <0.0001 | <0.0001 | |||
| Basal cell carcinoma | |||||
| First tertile (≤0.67) | 0.43 (0.13) | 123 (66.5%) | 122 (32.8%) | 1.00 (reference) | 1.00 (reference) |
| Second tertile (0.68-1.11) | 0.87 (0.13) | 44 (23.8%) | 125 (33.6%) | 0.35 (0.22 - 0.56) | 0.35 (0.21-0.57) |
| Third tertile (≥1.12) | 1.69 (0.70) | 18 (9.7%) | 125 (33.6%) | 0.10 (0.06 - 0.19) | 0.10 (0.06-0.19) |
| Ptrend | <0.0001 | <0.0001 |
1
Adjusted for age at blood draw and gender.
2
Adjusted for age at blood draw, gender, smoking status, eye color, history of blistering sunburn, presence of many moles on the body, and history of working outdoors.