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Amino acids adjacent to the IGNPTY motif are required for binding of LRP1 to SNX17. (A). Schematic diagrams of the wild-type and mutant C-terminal and N-terminal regions (T44-100 and T4-53, respectively) of the LRP1 tails. The IGNPTY and FTNPVY motifs are indicated as in Figure 1A. The upstream and downstream regions of the IxNPxY or FxNPxY motifs are shown in the gry boxes labeled A through D. (B). GST pull-down assays using the constructs depicted in A.
