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. Author manuscript; available in PMC: 2014 Jun 15.
Published in final edited form as: J Immunol. 2013 May 17;190(12):6004–6014. doi: 10.4049/jimmunol.1203552

Figure 4. Effector T cells are required for lamina propria APCs to acquire tolerogenic functions.

Figure 4

MHC II−/ − C57BL/6 mice adoptively transferred with 2D2 T cells and MHCII+/+ APCs were induced for EAE with MOG peptide. Donor APCs were harvested from the LP or SP of C57BL/6 mice (A–B) or Rag2−/ − C57BL/6 mice (C) recipient of agg Ig-MOG + STI or agg Ig-W + STI. Mice were monitored daily for clinical signs of disease. Data is representative of three individual experiments with 5 mice per group. LPIg-MOG, LPIg-W and SPIg-MOG refer to LP or SP APCs from mice treated with oral Ig-MOG or Ig-W.