Table I.

Lamina propria, but not splenic, APCs transfer T cell tolerance against diverse specificities^a

Mice	APC origin	Tolerogen	Disease onset	Recovery day	Mean maximal disease score	Cumulative disease score
C57BL/6
Rag 2+/+	LP	Ig-MOG	15.0 ± 1.0	34.5 ± 6.5	0.7 ± 0.3*1	11.5 ± 6.5*2
		Ig-W	14.0 ± 0.6	41.3 ± 1.5	1.7 ± 0.3	34.3 ± 1.1
	SP	Ig-MOG	15.0 ± 0.7	44.7 ± 0.3	1.7 ± 0.2	28.3 ± 4.3
		Ig-W	16.0 ± 0.7	43.3 ± 0.3	1.7 ± 0.2	25.0 ± 0.7
Rag 2−/ −	LP	Ig-MOG	10.2 ± 0.5	56.8 ± 1.6	2.0 ± 0.0	62.6 ± 2.1
		Ig-W	10.3 ± 0.4	55.3 ± 1.6	2.0 ± 0.0	62.9 ± 0.9
OTII
Rag 2+/+	LP	Ig-OVA	14.3 ± 1.5	37.7 ± 0.9	1.0 ± 0.0*3	12.5 ± 0.8*4
		Ig-MOG	10.6 ± 0.7	47.0 ± 3.5	2.0 ± 0.0	55.0 ± 1.6
		Ig-W	11.3 ± 0.7	50.0 ± 4.0	2.0 ± 0.0	59.8 ± 2.9
	SP	Ig-OVA	11.0 ± 0.6	56.0 ± 0.6	2.0 ± 0.0	57.8 ± 1.6

^aData represent 3 individual experiments with 5 mice per group and are presented as mean ± SE (by unpaired, two-tailed Student’s t test).

^*indicates statistical analysis between groups by unpaired, two-tailed Student’s t test or one-way ANOVA as indicated.

^*1p=0.047 (t test);

^*2p=0.026 (t test);

^*3p<0.0001 (ANOVA);

^*4p<0.0001 (ANOVA)