Table 2.
Bilateral infusions of bicuculline: locomotion and abnormal movements
| Case | Infusion sites | Abnormal movements | Fold differences in sequential trials | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||
| Right side | Left side | pivoting | 1 | 2 | 3 | 4 | 5 | 6 | ||||
| gnawing | ||||||||||||
| grasping | ||||||||||||
| galloping | ||||||||||||
| A. | ||||||||||||
| 11017 | lVP | lVP, VPtu | 0.11 | |||||||||
| 11018 | vmCPu | vmCPu | 0.69 | |||||||||
| 11038 | vBST, VP | vmCPu, dVP | X | X | 0.39 | 0.36 | ||||||
| 11039 | VP | vmCPu, dVP | 1.53 | 1.30 | ||||||||
| 11053 | VP | VP | X | X | 5.95 | 2.90 | ||||||
| 11063 | Acb, VP, CPu | VP, VPtu | X | X | 1.42 | 0.51 | 0.38 | |||||
| 11068 | VPtu | mTu (Str&VP) | 2.39 | 1.78 | 1.37 | |||||||
| 11070 | lVP,VPtu | VP, VPtu | 0.94 | 1.85 | 2.05 | |||||||
| 11231 | CPu, lVP | VP | 4.37 | 1.57 | ||||||||
| 12044 | VP | VP, VPtu | X | X | 0.93 | 1.60 | 1.30 | |||||
| 12045 | VP | VP | X | X | 1.02 | 0.87 | 0.67 | |||||
| 12047 | VP, CPu | VP | X | X | 1.43 | 1.51 | 1.07 | |||||
| 12048 | VP, VPtu | vCPu, VP | X | X | 0.95 | 2.58 | 2.21 | |||||
| 12049 | vmCPu, VP | vmCPu, VP | X | X | 2.41 | 2.95 | 3.96 | |||||
| 13094 | vmCPu, VP | vmCPu, VP | X | X | X | 0.83 | 2.35 | 1.80 | 3.48 | 1.39 | 0.10 | |
| 13096 | vGP, VP | vGP, VP | X | X | 1.04 | 0.68 | 2.55 | 2.46 | 0.06 | |||
| 13097 | VP | VP | X | X | 0.92 | 0.88 | 1.58 | 0.40 | 0.17 | 0.14 | ||
| 13098 | VP | VP | X | X | 0.62 | 0.83 | 2.09 | 2.04 | 0.06 | 0.23 | ||
| 13106 | VP | VP | X | 1.53 | 0.88 | |||||||
| 13107 | VP | VP | X | X | 1.77 | 1.76 | ||||||
| 13109 | VP | VP | X | X | 0.68 | 0.77 | ||||||
| 13110 | VP | VP | X | X | 0.45 | 0.66 | ||||||
| B. | ||||||||||||
| 11052 | VP, LPO, vBST | VP, LPO | X | X | 2.12 | 2.99 | ||||||
| 11062 | VP, LPO | clVP | 4.82 | 10.7 | 2.82 | 4.59 | ||||||
| 11066 | clVP, HDB | cmVP, LPO | X | X | 0.98 | 4.29 | 4.50 | |||||
| 11067 | vCPu, cAcb | VP, cmCPu, BST | X | X | 0.63 | 0.28 | 1.77 | 1.34 | ||||
| 11069 | lVP, VPtu | mTu (Str), LPO | X | X | 3.47 | 6.73 | 4.34 | |||||
| 11230 | VP, LPO | CPu | X | X | 1.17 | 6.18 | ||||||
| 11232 | VP, vCPu, BST | VP, vCPu, BST | 3.47 | 3.77 | ||||||||
| 12046 | VP, LPO | VP | X | X | 1.04 | 2.84 | 4.94 | |||||
A. Cases (not included in Table 1) in which infusion sites involved the ventral pallidum (VP) and other indicated structures, but not the lateral preoptic area (LPO), on both sides of the midline. Abnormal movements are as described in the the text. Fold difference is beam breaks/20 minutes following bicuculline infusion]/[ beam breaks/20 minutes following saline infusion] (see Methods). Fold difference values more than 3.0 are bolded and undescored for emphasis.
B. Cases in which the infusion site on at least one side of the midline involved the LPO or transition area between the VP and LPO.
Note the greater density of bolded entries in section B.
Additional abbreviations: Acb - accumbens; BST - bed nucleus of stria terminalis; c - caudal; CPu - caudate-putamen; GP - globus pallidus; HDB - horzontal limb of the diagonal band; m - medial; l - lateral; Str - striatal, as in the striatal part of the olfactory tubercle; VPtu - ventral pallidum occupying the deep layer of the olfactory tubercle