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. Author manuscript; available in PMC: 2014 Jul 5.
Published in final edited form as: Eur J Pharmacol. 2013 Apr 30;711(0):50–56. doi: 10.1016/j.ejphar.2013.04.020

Figure 4. BRL37344 effects on the amplitude of the 0.5–50 Hz EFS-induced contractions of rat DSM isolated strips in the presence of suramin and α,β-methylene-ATP.

Figure 4

This original DSM tension recording of EFS-induced DSM cholinergic contractions illustrates BRL37344 (100 µM) inhibitory effects in the absence (A) or presence (B) of SR59230A (10 µM). Application of α,β-methylene-ATP, a purinergic receptor agonist caused a transient contraction (A and B) of the DSM followed by desensitization and inhibition of the receptor. C-D) These EFS frequency-response curves show BRL37344 inhibitory effect on EFS-induced DSM contraction amplitude in the absence (n=12, N=5) (C) or presence (D) of 10 µM SR59230A (n=9, N=5; ***P<0.005).