Skip to main content
. Author manuscript; available in PMC: 2014 Jul 5.
Published in final edited form as: Eur J Pharmacol. 2013 Apr 30;711(0):50–56. doi: 10.1016/j.ejphar.2013.04.020

Figure 5. Blockade of BK channels with iberiotoxin reduces the BRL37344 inhibitory effects on 20 Hz EFS-induced contractions of rat DSM isolated strips.

Figure 5

A) This original DSM tension recording illustrates the reduction of BRL37344 (10 nM–100 µM) inhibitory effects on 20 Hz EFS-induced DSM contractions by BK channels blockade with 200 nM iberiotoxin. These cumulative concentration-response curves show that pretreatment of DSM isolated strips with 200 nM iberiotoxin opposes BRL37344 inhibitory effects on EFS-induced DSM contraction amplitude (B) and force (C) (n=7, N=5; *P<0.05).