Fig. 2.

RAR structure. (A) RARs depict a domain organization with an unstructured NTD and two well-structured domains: a central DBD and a C-terminal LBD. The phosphorylation sites located in the NTD and the LBD are shown. (B) Structural changes induced upon RA binding. The crystal structures of the unliganded RXRα and liganded RARγ LBDs are shown. Helices are represented as ribbons and labeled from H1 to H12. The binding domains for corepressors/coactivators and for cyclin H are shown. Adapted from Protein Data Bank 1lbd and 2lbd.