Fig. 6.

Crosstalk between the RA-activated p38MAPK pathway and the expression of RAR target genes. In response to RA, p38MAPK is activated (a), and then translocates into the nucleus and phosphorylates MSK1 (b). Activated MSK1 phosphorylates histones (c) and RARα at a serine located in the LBD (d). Subsequent to conformational changes, the cyclin H subunit of the CAK subcomplex of TFIIH is recruited to an adjacent domain (e), allowing the formation of a RARα/TFIIH complex and the phosphorylation of the NTD by the cdk7 kinase (f). In the case of the RARγ subtype, phosphorylation of the NTD promotes the dissociation of coregulators, such as vinexinß (g). Finally, phosphorylated RARα is recruited to response elements located in the promoter of target genes (h).