Table 2. Incidence of tumors by MCF-7 mammosphere and adherent cells in nude mice following the shRNA-mediated silencing of Beclin 1.
Number of cells inoculated | 5 × 106 | 5 × 104 | 5 × 102 |
---|---|---|---|
Mammosphere MCF-7 shSCR | 5/5 | 5/5 | |
Mammosphere MCF-7 shBECN1 | 3/5 | 2/5 | |
Adherent MCF-7 shSCR | 5/5 | 2/5 | |
Adherent MCF-7 shBECN1 | 4/5 |
Abbreviations: shBECN1, Beclin 1 shRNA; shSCR, scrambled control shRNA; shRNA, short hairpin RNA.