Table 2.
Mortality by subgroup analysis
| Number of studies | Number of patients in GDT group | Mortality in GDT group (%) | Number of patients in control group | Mortality in control group (%) | Odds ratio | 95% CI | P-value | |
|---|---|---|---|---|---|---|---|---|
| Risk group | ||||||||
| Intermediate risk | 15 | 807 | 16 (2.0) | 762 | 17(2.2) | 0.83 | 0.41-1.69 | 0.62 |
| High risk | 12 | 489 | 31 (6.3) | 435 | 45 (10.3) | 0.65 | 0.39-1.07 | 0.09 |
| Extremely high risk | 5 | 142 | 11 (7.7) | 173 | 51 (29.5) | 0.2 | 0.09-0.41 | <0.0001 |
| Fluid/inotropes | ||||||||
| Fluid | 16 | 732 | 25 (3.4) | 738 | 38 (5.1) | 0.72 | 0.42-1.23 | 0.23 |
| Fluid + inotrope | 16 | 706 | 33 (4.7) | 632 | 75 (11.9) | 0.41 | 0.23-0.73 | 0.002 |
| Goal | ||||||||
| Supranormal | 9 | 365 | 19 (5.2) | 351 | 65 (18.5) | 0.27 | 0.15-0.47 | <0.00001 |
| Normal | 23 | 1073 | 39 (3.6) | 1,019 | 48 (4.7) | 0.80 | 0.51-1.27 | 0.35 |
| Target | ||||||||
| CI/DO2I | 15 | 674 | 30 (4.5) | 592 | 73 (12.3) | 0.36 | 0.21-0.36 | 0.0003 |
| FTc/SV | 9 | 423 | 15 (3.5) | 434 | 23 (5.3) | 0.78 | 0.40-1.52 | 0.46 |
| Other | 8 | 341 | 13 (3.8) | 344 | 17 (4.9) | 0.78 | 0..35-1.72 | 0.54 |
| Type of monitor | ||||||||
| PAC | 11 | 494 | 20 (4.0) | 445 | 62 (13.9) | 0.3 | 0.15-0.6 | 0.0007 |
| ODM | 8 | 378 | 10 (2.6) | 389 | 17 (4.4) | 0.77 | 0.35-1.69 | 0.51 |
| Other | 13 | 566 | 28 (4.9 | 536 | 34 (6.3) | 0.74 | 0.43-1.28 | 0.28 |
CI, cardiac index (ml/minute/m2); DO2I, oxygen delivery index (ml/minute/m2); FTc, corrected flow time; ODM, oesophageal doppler monitor; PAC, pulmonary artery catheter; SV, stroke volume (ml).