Table 3.
Complications by subgroup analysis
| Number of studies | Number of patients in GDT group | Patients with complications in GDT group (%) | Number of patients in control group | Patients with complications in control group (%) | Odds ratio | 95% CI | P-value | |
|---|---|---|---|---|---|---|---|---|
| Risk group | ||||||||
| Intermediate risk | 13 | 727 | 194(26.7) | 698 | 288 (41.3) | 0.43 | 0.27-0.67 | 0.0002 |
| High risk | 10 | 449 | 149 (33.2) | 395 | 184 (46.6) | 0.56 | 0.36-0.89 | 0.01 |
| Extremely high risk | 4 | 89 | 25 (28.1) | 119 | 67 (56.3) | 0.27 | 0.15-0.51 | <0.0001 |
| Fluid/inotropes | ||||||||
| Fluid | 12 | 610 | 198 (32.5) | 636 | 299 (47.0) | 0.47 | 0.30-0.73 | 0.0007 |
| Fluid + inotrope | 15 | 653 | 170 (26.0) | 578 | 240 (41.5) | 0.44 | 0.30-0.64 | <0.0001 |
| Goal | ||||||||
| Supranormal | 8 | 312 | 101 (32.4) | 297 | 153 (51.5) | 0.34 | 0.23-0.51 | <0.00001 |
| Normal | 19 | 951 | 267 (28.1) | 917 | 386 (42.1) | 0.51 | 0.36-0.73 | 0.0002 |
| Target | ||||||||
| CI/DO2I | 14 | 621 | 162 (26.1) | 538 | 229 (42.6) | 0.41 | 0.28-0.61 | <0.0001 |
| FTc/SV | 7 | 361 | 118 (32.7) | 392 | 180 (45.9) | 0.50 | 0.30-0.84 | 0.009 |
| Other | 6 | 281 | 88 (31.3) | 284 | 130 (45.8) | 0.48 | 0.22-1.04 | 0.06 |
| Type of monitor | ||||||||
| PAC | 10 | 441 | 99 (22.4) | 391 | 129 (33.0) | 0.49 | 0.30-0.80 | 0.005 |
| ODM | 6 | 316 | 92 (29.1) | 347 | 150 (43.2) | 0.46 | 0.25-0.86 | 0.01 |
| Other | 1! | 506 | 177 (35.0) | 476 | 260 (54.6) | 0.41 | 0.26-0.64 | 0.0001 |
CI, cardiac index (ml/minute/m2); DO2I, oxygen delivery index (ml/minute/m2); FTc, corrected flow time; ODM, oesophageal doppler monitor; PAC, pulmonary artery catheter; SV, stroke volume (ml)