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. 2013 Mar 22;20(7):878–887. doi: 10.1038/cdd.2013.21

Figure 1.

Figure 1

Inhibition of hepatocyte autophagy increases GalN/LPS liver injury. (a) Serum ALT levels in littermate controls (Con) and Atg7Δhep (KO) mice untreated (0 h) and at 1 and 2 h after GalN/LPS administration (*P<0.001 as compared with control mice; n=9–10). (b) Histological grade of liver injury in untreated and GalN/LPS-treated mice (*P<0.03 as compared with control mice; n=5–7). (c) Serum ALT levels at 4 and 6 h (*P<0.0001 as compared with control mice; n=5–10). (d) Numbers of TUNEL-positive cells per high power field (HPF; *P<0.05; **P<0.006; n=3–8). (e) Histological grade of hepatic inflammation (*P<0.02 as compared with control mice; n=5–7). (f) Survival curve after GalN/LPS treatment (P<0.001; n=14–31)