Knockout livers have increased histological liver injury and TUNEL staining. Hematoxylin and eosin stained liver sections from control (a) and knockout (b) mice 4 h after GalN/LPS administration. TUNEL staining in control (c, e) and knockout (d, f) livers at 2 h (c, d) and 4 h (e, f) after GalN/LPS. Magnifications for all, × 400