Table 2. Genotypes of pups from breeding 40 pairs of Abl+/μp53+/−compound heterozygous mice.
| Genotypea | No. of pupsb | % expected frequency | % observed frequency | Male to female ratio |
|---|---|---|---|---|
| Abl+/+p53+/+ | 62 | 6.25 | 9.2 | 1.3 |
| Abl+/μp53+/+ | 99 | 12.5 | 14.6 | 1.1 |
| Ablμ/μp53+/+ | 60 | 6.25 | 8.9 | 1.1 |
| Abl+/+p53+/− | 96 | 12.5 | 14.2 | 0.9 |
| Abl+/μp53+/− | 181 | 25 | 26.7 | 1.0 |
| Ablμ/μp53+/− | 71 | 12.5 | 10.5 | 1.8 |
| Abl+/+p53−/− | 35 | 6.25 | 5.2 | 1.7 |
| Abl+/μp53−/− | 49 | 12.5 | 7.2 | 2.1 |
| Ablμ/μp53−/− | 24 | 6.25 | 3.5 | 5.0 |
a
Abl genotype: wild type (+) or μNLS (μ); p53 genotype: wild type (+) or null (−), was determined as described in Materials and Methods, and Supplementary Figure s1
b
Total number of pups=677; male=376; female=301