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Autophagy overlaps with the extrinsic apoptosis pathway in liver cells. Deficient autophagy results in overactivation of JNK, which increases caspase-8 activation and allows the induction of TNF-dependent apoptosis. How autophagy regulates JNK activity remains still unknown. In addition, several canonical pro-apoptotic molecules, such as caspase-8, can be degraded by autophagy
