Table 2.

Histological review of mouse lungs.

	Airway inflammation (%)	Parenchymal inflammation (%)	Pigmented macrophages (%)	Pneumocyte hyperplasia (%)
CD-NS	44	78	0	22
VDD-NS	55	73	18	45
CD-CSE	0	67	75*	0
VDD-CSE	36	55	91*	18

Sections of H&E-stained mouse lung were reviewed for the presence/absence of the four histologic features indicated in Table 2. The frequency of occurrence of these features is represented as percentages of animals within each treatment group in which the histological feature was observed. All of the inflammation in these cases was chronic (lymphocytic); there were no cases that showed acute (neutrophil) cells.

^*Indicates a significant increase in a particular feature compared to control animals (CD-NS) at the p < 0.05 level.