Table 3.

Relationship between maternal late-pregnancy maternal 25-hydroxyvitamin D status and offspring asthma and wheeze at age 6 years

	Univariable Model				Final model
	RR	(95% CI)	P-value	n	RR	(95% CI)	P-value	n
Current doctor-diagnosed asthma at 6 years	0.97	(0.91, 1.04)	0.36	860	0.98	(0.92, 1.04)	0.56	836
Current wheeze at 6 years	0.98	(0.92, 1.03)	0.40	860	0.99	(0.94, 1.05)	0.76	833
Any wheeze at or before 6 years	1.00	(0.98, 1.01)	0.61	856	1.00	(0.98, 1.02)	0.95	823
Transient wheeze	1.00	(0.98, 1.02)	0.85	719	1.00	(0.98, 1.02)	0.89	707
Persistent/late wheeze	0.98	(0.93, 1.03)	0.37	489	0.98	(0.94, 1.03)	0.49	475
Persistent/late wheeze with atopy	0.90	(0.81, 0.99)	0.03	257	0.91	(0.84, 0.99)	0.04	251
Persistent/late wheeze without atopy	0.99	(0.91, 1.06)	0.73	259	1.01	(0.94, 1.09)	0.73	253

Data presented as change in relative risk per 10 nmol/l change in maternal serum 25-hydroxyvitamin D status at 34 weeks’ pregnancy.

Adjusted models: asthma - maternal education, maternal asthma, paternal asthma and paternal rhinitis; wheeze at age 6 - maternal education, maternal asthma, paternal rhinitis, pets in the home during the child’s infancy; wheeze at or before 6 years - maternal BMI, child’s gender, maternal education, maternal asthma, paternal asthma, maternal rhinitis; transient wheeze - maternal BMI, child’s gender, mother’s parity, maternal asthma, maternal rhinitis; Persistent/late - maternal education, smoking during pregnancy, maternal asthma, paternal asthma, maternal rhinitis; Persistent/late wheeze with atopy-child’s gender, maternal asthma, paternal asthma, paternal rhinitis, pets in the home during infancy; Persistent/late wheeze without atopy-maternal age, smoking during pregnancy, maternal asthma, paternal asthma, pets in the home during infancy.