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. 2013 May 28;2013:741303. doi: 10.1155/2013/741303

Figure 3.

Figure 3

CB2R partially mediates the inhibitory effects of GW405833 on ConA-induced TNF-α and IL-6 production in splenocytes. (a)-(b) Splenocytes isolated from CB2R+/+ mice were treated with vehicle or ConA (5 μg/mL) in the absence or presence of GW405833 (1–10 μM) for 24 h. The levels of IL-6 and TNF-α in the supernatants were detected by ELISA. Data are means ± SD (n = 3), *P < 0.05, and **P < 0.01 versus ConA. (c)-(d) Splenocytes isolated from CB2R+/+ and CB2R−/− mice were treated with ConA (5 μg/mL) in the absence or presence of GW405833 (10 μM) for 24 h. The levels of IL-6 and TNF-α in the supernatants were detected by ELISA. Data are means ± SD (n = 3), *P < 0.05, and **P < 0.01.