Table 4.
Association between maternal cytokine gene polymorphisms and newborns’ biological parameters: multivariate analysis
| Maternal cytokine gene (n) | Haemoglobin (g/dl) (SD)a | Pb | Anaemia OR [CI95]c | Pd |
|---|---|---|---|---|
|
IL-10−1082 genotypes: |
|
|
|
|
| GG (47) |
15.1 (0.3) |
|
|
|
| GA and AA (529) |
14.6 (0.3) |
0.07 |
OR GA and AA vs GG = 1.81 [0.98-3.32] |
0.06 |
|
IL-10−819 genotypes: |
|
|
|
|
| CC (191) |
14.8 (0.2) |
|
|
|
| CT and TT (385) |
14.6 (0.2) |
0.14 |
OR CT and TT vs CC = 1.46 [1.02-2.10] |
0.04 |
|
IL-10−592 genotypes: |
|
|
|
|
| CC (191) |
14.7 (0.1) |
|
|
|
| CA and AA (385) |
14.4 (0.2) |
0.13 |
OR CA and AA vs CC = 1.36 [0.95-1.95] |
0.09 |
|
IL-10−1082/IL-10−819/IL-10−592 haplotypes: |
|
|
|
|
| No IL10-ATA (196) |
14.8 (0.2) |
|
|
|
| 1 or 2 copies IL10-ATA (380) | 14.6 (0.2) | 0.13 | OR 1 or 2 copies IL10-ATA vs. no IL10-ATA = 1.45 [1.02-2.08] | 0.04 |
a 5 missing values.
b analysis adjusted on maternal anaemia (Hb < 11 g/dl) and low birthweight (< 2500 g).
c newborn’s anaemia defined as Hb < 15 g/dl.
d analysis adjusted on maternal anaemia and age.
P values < 0.05 are in bold.