Table 5.
Association between maternal cytokine gene polymorphisms and antibody levels to P. falciparum antigens in mothers: multivariate analysis
| Antibody response | Maternal cytokine gene (n) | Antibody levels (μg/ml)a(SD) | P |
|---|---|---|---|
| IgM to AMA-1 |
|
|
|
| |
IL-10−1082 genotypes: |
|
|
| |
GG (47) |
13.9 (3.3) |
|
| |
GA (223) |
17.0 (3.5) |
0.08 b |
| |
AA (306) |
20.0 (3.7) |
|
| IgG to MSP-1 |
|
|
|
| |
IL-4−590 genotypes: |
|
|
| |
CC and CT (218) |
49.0 (5.5) |
|
| |
TT (358) |
32.8 (7.0) |
0.02c |
| IgG to MSP-2/3D7 |
|
|
|
| |
IL-4−590 genotypes: |
|
|
| |
CC and CT (218) |
95.5 (10.3) |
|
| |
TT (358) |
70.3 (11.9) |
0.03d |
| |
IL-10−1082 genotypes: |
|
|
| |
GG and GA (270) |
68.2 (6.2) |
|
| |
AA (306) |
92.9 (12.2) |
0.04d |
| IgG to MSP-2/FC27 |
IL-4−590 genotypes: |
|
|
| |
CC (25) |
147.7 (61.7) |
|
| |
CT (193) |
98.0 (62.7) |
|
| |
TT (358) |
85.4 (62.8) |
0.02b |
| IgG to GLURP-R2 e |
|
|
|
| |
IL-4−590 genotypes: |
|
|
| |
CC (25) |
23.2 (6.9) |
|
| |
CT and TT (551) |
38.3 (7.6) |
0.05 d |
| |
IL-10−1082/IL-10−819/IL-10−592 haplotypes: |
|
|
| |
No or 1 copy IL10-ATA (489) |
38.6 (3.0) |
|
| 2 copies IL10-ATA (87) | 24.6 (7.6) | 0.07 d |
a median value.
b analysis adjusted on village.
c analysis adjusted on presence of P. falciparum circulating parasites in mothers and presence of placental parasites.
d analysis adjusted on presence of placental parasites.
e 5 missing values.
P values < 0.05 are in bold.