Figure 4.

Effects of WXKL on the calcium transient and the Ca²⁺ content in the SR measured in vitro at 4 weeks after treatment. (a) The calcium transient amplitude was measured by stimulating the cultured adult cardiomyocytes at 0.5 Hz. (b) Compared with the sham group, the calcium transient amplitude was reduced in the MI group, the WXKL group, and the amiodarone group (P < 0.05,  n = 15 cells per group). Compared with that of the MI group, the calcium transient amplitude was significantly elevated in the WXKL group and the amiodarone group (P < 0.05). (c) The Ca²⁺ content in the SR was measured by assessing caffeine-induced calcium release in cultured adult cardiomyocytes. (d) The integrative volumes of the Ca²⁺ transients in the WXKL-treated group and the amiodarone group were increased significantly compared with those of the MI group (P < 0.05,  n = 12 cells per group). (*P < 0.05 versus the MI group, ^▲ P < 0.05 versus the sham group).