Table 1.
Comparison between whole blood and cerebrospinal fluid fatty acids levels
|
Fatty acid |
Whole blooda(%) |
CSFa(%) |
|||||
|---|---|---|---|---|---|---|---|
| C:Dn-x | Common name | Mean (±SE) | Min | Max | Mean (±SE) | Min | Max |
| C16:0 |
palmitic acid |
23.37 (0.43) |
18.77 |
27.68 |
27.88 (0.76) |
14.77 |
55.55 |
| C16:1n-7 |
palmitoleic acid |
2.56 (0.15) |
0.75 |
4.43 |
2.71 (0.18) |
0.89 |
7.24 |
| C18:0 |
stearic acid |
8.68 (0.28) |
6.59 |
11.55 |
18.70 (0.78) |
9.79 |
41.11 |
| C18:1n-7 |
vaccenic acid |
2.22 (0.08) |
1.48 |
3.31 |
3.76 (0.17) |
0.00 |
7.61 |
| C18:1n-9 |
oleic acidc |
21.21 (0.50) |
15.8 |
26.17 |
25.48 (0.61) |
11.74 |
33.94 |
| C18:2n-6 |
linoleic acid |
20.40 (0.53) |
13.33 |
26.04 |
7.01 (0.33) |
2.87 |
17.47 |
| C18:3n-3 |
alpha-linolenic acid |
0.74 (0.04) |
0.46 |
1.42 |
2.54 (0.26) |
0.59 |
16.14 |
| C18:3n-6 |
gamma-linolenic acid |
1.52 (0.06) |
0.98 |
2.06 |
ND |
- |
- |
| C20:0 |
arachidic acid |
0.26 (0.02) |
0.12 |
0.51 |
ND |
- |
- |
| C20:1n-9 |
eicosenoic acid |
0.24 (0.01) |
0.17 |
0.37 |
1.21 (0.14) |
0.00 |
6.14 |
| C20:2n-6 |
eicosadienoic acid |
1.17 (0.08) |
0.30 |
2.01 |
ND |
- |
- |
| C20:3n-6 |
dihomo-gamma-linolenic acid |
1.73 (0.05) |
1.07 |
2.31 |
1.02 (0.12) |
0.00 |
4.84 |
| C20:4n-6 |
arachidonic acidb |
8.00 (0.38) |
4.78 |
12.47 |
3.47 (0.20) |
0.99 |
9.00 |
| C20:5n-3 |
eicosapentaenoic acid |
2.01 (0.15) |
1.04 |
3.87 |
1.87 (0.28) |
0.00 |
10.66 |
| C22:5n-3 |
docosapentaenoic acidc |
1.98 (0.10) |
1.06 |
3.17 |
2.94 (0.18) |
0.84 |
8.46 |
| C22:6n-3 |
docosahexaenoic acidc |
3.91 (0.17) |
2.54 |
5.92 |
1.41 (0.12) |
0.00 |
5.70 |
| Total SFA |
32.31 (0.28) |
29.06 |
35.20 |
46.58 (1.27) |
24.57 |
75.94 |
|
| Total MUFAb |
26.26 (0.57) |
18.92 |
31.71 |
33.16 (0.69) |
14.55 |
41.21 |
|
| Total omega-3 PUFAc |
8.64 (0.33) |
6.05 |
12.66 |
8.76 (0.55) |
2.65 |
28.52 |
|
| Total omega-6 PUFA |
32.80 (0.53) |
25.63 |
38.79 |
11.50 (0.49) |
4.85 |
23.53 |
|
| Ratio omega-6:omega-3 | 3.92 (0.13) | 2.73 | 5.54 | 1.47 (0.07) | 0.41 | 3.45 | |
Fatty acids are expressed as a percentage of total fatty acids.
an = 28, bP < 0.05 for comparison between respective whole blood and CSF fatty acid concentrations using multiple linear regression.
cP < 0.05 for comparison between whole blood total omega-3 PUFA and CSF DPA (C22:5n-3) and DHA (C22:6n-3) using multiple linear regression.
ND not detected.