Table 2.
Anticancer Nucleoside Analogs**
| Nucleoside Analog | Abbreviation | Analogous to: | Used to Treat: | Toxicity |
|---|---|---|---|---|
| Gemcitabine | dFdC | Cytidine | ovarian cancer, breast cancer, pancreatic cancer, non-small cell lung cancer | Anemia, neutropenia, thrombocytopenia, pulmonary toxicity, hepatic impairment, renal impairment |
| Cytarabine | ARA-C | Cytidine | acute nonlymphocytic leukemia, acute lymphocytic leukemia | Anemia, neutropenia, thrombocytopenia, renal impairment, stomatitis, peripheral neuropathy |
| Clofarabine | Cl-F-ARA-A | Adenosine | acute lymphoblastic leukemia | Anemia, neutropenia, thrombocytopenia, hepatic impairment, renal failure, systemic inflammatory response syndrome |
| Cladribine | CdA | Adenosine | Hairy cell leukemia | Anemia, neutropenia, thrombocytopenia, peripheral neuropathy, renal failure |
| Fludarabine | F-ARA-A | Adenosine | chronic B-cell lymphocytic leukemia | Anemia, neutropenia, thrombocytopenia, pulmonary toxicity, autoimmune reaction, neurological toxicity |
| Azacitidine | 5-AZC, 5-AC | Cytidine | myelodysplastic syndromes, chronic myelomonocytic leukemia | Anemia, neutropenia, thrombocytopenia, hepatic impairment, renal impairment and failure |
| Decitabine | DAC, 5-AZA | Cytidine | myelodysplastic syndromes, chronic myelomonocytic leukemia | Anemia, neutropenia, thrombocytopenia, neurological reactions |
| Nelarabine | ARA-G | Guanosine | T-cell acute lymphoblastic leukemia, T-cell lymphoblastic lymphoma | Anemia, neutropenia, thrombocytopenia, neurological reactions |
| Pentostatin | dCF | Adenosine | Hairy cell leukemia | Anemia, neutropenia, thrombocytopenia, peripheral neuropathy, hepatic impairment |