Table 1.

Selected DEG for paired irradiated versus non-irradiated skin

Gene symbol/protein	Description	Gene chip FCH a, b	PCR FCH	PCR p value
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	149.3
DEFB4A/HBD2	Defensin, beta 4A	73.0
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	60.7	5.8	5.3 × 10−4
CCL20	chemokine (C-C motif) ligand 20	52.2	8.3c	2.6 × 10−3
PI3/Elafin	peptidase inhibitor 3, skin-derived	45.1
MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	44.6
CXCL2	chemokine (C-X-C motif) ligand 2	35.9
IL6	Interleukin 6	33.5
S100A9	S100 calcium binding protein A9	28.7
CXCL3	chemokine (C-X-C motif) ligand 3	26.5
IL8	Interleukin 8	24.4	10.5	2.7 × 10−4
S100A7	S100 calcium binding protein A7	14.4
CCL8	chemokine (C-C motif) ligand 8	14.1
PTGS2	Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	11.1
CCR1	Chemokine (C-C motif) receptor 1	10.9
CCL18	Chemokine (C-C motif) ligand 18	9.9
S100A8	S100 calcium binding protein A8	9.0
S100A12	S100 calcium binding protein A12	8.5
ICAM1	Intercellular adhesion molecule 1	6.7
KRT16	Keratin 16	6.0
CCL2	Chemokine (C-C motif) ligand 2	5.6	3.4	7.9× 10−3
IL1B	Interleukin 1, beta	5.5
CD209	CD209 molecule	5.03
CD163	CD163 molecule	4.8
IL4R	Interleukin 4 receptor	4.2
CCR7	Chemokine (C-C motif) receptor 7	3.7
IL24	Interleukin 24	3.6
CCR2	Chemokine (C-C) receptor 2	3.4
CD14	CD14 molecule	3.4
CCL22	Chemokine (C-C) ligand 22	3.3
TLR2	Toll-like receptor 2	2.9
CD83	CD83 molecule	2.8
S100A2	S100 calcium binding protein A2	2.6
IL15	Interleukin 15	2.1
CD207	CD207 molecule, langerin	−9.8
CD1A	CD1A molecule	−7.7
IL-10			2.5	3.6 × 10−3

^aFCH = Fold-change in gene expression from microarray data

^bFDR < 0.01 for all genes

^cPreviously published (Kennedy-Crispin et al., 2012)