TABLE 1.
Description of Subjects From the COPDGene Study Cohort Used in This Study
| Variable | Nonsmokers, No Emphysema
|
Smokers, No Emphysema
|
Smokers, Centrilobular Emphysema
|
|||
|---|---|---|---|---|---|---|
| Training (n = 12) | Evaluation (n = 25) | Training (n = 12) | Evaluation (n = 24) | Training (n = 12) | Evaluation (n = 22) | |
| Subject data | ||||||
| Men/women | 3/9 | 7/18 | 6/6 | 15/9 | 7/5 | 9/13 |
| Age at enrollment (y) | 61.2 ± 7.2 | 61.5 ± 8.0 | 60.2 ± 11.2 | 59.6 ± 7.8 | 64.2 ± 10.0 | 67.5 ± 7.6 |
| BMI (kg/m2) | 25.5 ± 3.1 | 28.6 ± 5.8 | 30.0 ± 5.3 | 32.9 ± 5.9 | 29.7 ± 7.4 | 26.0 ± 5.2 |
| Smoking history | ||||||
| Start age (y) | NA | NA | 16.0 ± 2.0 | 17.0 ± 14.7 | 17.6 ± 7.5 | 17.7 ± 3.8 |
| Current smokers (yes/no) | NA | NA | 5/7 | 6/18 | 6/6 | 4/18 |
| Stop age (y) | NA | NA | 42.0 | 49.0 | 55.3 | 58.9 |
| Cigarettes/day | NA | NA | 21.1 ± 11.9 | 27.7 ± 14.7 | 30.3 ± 15.1 | 26.1 ± 10.7 |
| ATS pack-years | NA | NA | 31.7 ± 15.6 | 46.2 ± 29.8 | 58.3 ± 26.4 | 54.1 ± 25.1 |
| CT scanner | ||||||
| Siemens/GE | 11 (2)/1 | 21 (4)/4 | 9 (2)/3 (2) | 18 (3)/6 (2) | 9 (2)/3 (2) | 19 (3)/3 (2) |
| Number of study centers | 5 | 6 | 5 | 9 | 6 | 7 |
| VIDA image processing | ||||||
| Total lung capacity (mL) | 5445 ± 852 | 5125 ± 1046 | 6103 ± 1371 | 5600 ± 1217 | 6453 ± 1738 | 5866 ± 1148 |
| % LAA* | 1.1 ± 1.1 | 1.3 ± 0.9 | 4.4 ± 3.2 | 3.5 ± 4.0 | 10.1 ± 5.1 | 17.6 ± 8.4 |
| % air trapping† | 4.6 ± 3.1 | 10.0 ± 6.3 | 16.4 ± 13.6 | 11.5 ± 7.1 | 26.1 ± 11.4 | 41.4 ± 16.8 |
ATS, American Thoracic Society; BMI, body mass index; COPDGene, Genetic Epidemiology of COPD; CT, computed tomographic; LAA, low-attenuation area; NA, not applicable.
Data are expressed as mean ± standard deviation or as numbers.
*
Computed as percentage voxels ≤−950 Hounsfield units on inspiratory CT scans.
†
Calculated as percentage voxels ≤−856 Hounsfield units on expiratory CT scans.