. Author manuscript; available in PMC: 2013 Aug 1.

Published in final edited form as: Nat Genet. 2012 Dec 23;45(2):191–196. doi: 10.1038/ng.2505

Table 2.

Association of colorectal cancer risk with the three newly-identified risk variants in European-ancestry populations and the meta-analyses of East Asians and Europeans

SNP	Alleles^a	MAF^b		Europeans^c			East Asians and Europeans combined^c
SNP	Alleles^a	Cases	Controls	Cases/controls	OR (95% CI)	P_meta	Cases/controls	OR (95% CI)	P_meta
rs10774214	T/C	0.385	0.379	11,870/14,190	1.04 (1.00–1.09)	0.040	19,165/25,736	1.09 (1.06–1.13)	3.06×10⁻⁸
rs647161	A/C	0.680	0.667	11,870/14,190	1.07 (1.02–1.11)	0.002	19,185/25,754	1.11 (1.08–1.15)	1.22×10⁻¹⁰
rs2423279	C/T	0.263	0.252	11,870/14,190	1.07 (1.03–1.12)	0.001	19,195/25,750	1.10 (1.06–1.14)	6.64×10⁻⁹

Alelles (minor/major) as shown in Table 2 for East Asians.

Minor allele frequency (MAF) in European-ancestry populations.

Summary statistics were generated using inverse-variance weighted, fixed-effects meta-analysis.