Table 1.
Summary of the main parameters evaluated for the embryotoxicity studies
| ♀ | Mean No. fetuses/female | CRL | Fetal weight (mg) | ♀ with malformed fetuses | Total No. of resorptions | |
|---|---|---|---|---|---|---|
| CTRL |
18 |
13.7 ± 1.3 |
1.57 ± 0.15 |
401 ± 11 |
0 |
14 |
| 100 ng/mouse |
5 |
12.3 ± 1.3 |
1.60 ± 0.21 |
396 ± 9 |
0 |
3 |
| 10 μg/mouse |
10 |
14.0 ± 0.4 |
1.57 ± 0.14 |
412 ± 3 |
0 |
7 |
| 30 μg/mouse |
10 |
12.9 ± 0.7 |
1.52 ± 0.12 |
399 ± 14 |
1/10 (1 fetus) |
8 |
| CTRL 3 × 10 |
10 |
12.2 ± 1.0 |
1.61 ± 0.11 |
392 ± 15 |
0 |
8 |
| 3 × 10 μg/mouse | 10 | 12.7 ± 1.8 | 1.58 ± 0.10 | 395 ± 17 | 2/10 (3 + 2 fetuses) | 7 |
♀: number of females analyzed.
CRL: crown rump length.