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Parameter values that are consistent when fitting Equations (4a)–(4d) to the Ma et al. data
| Parameter | Value |
|---|---|
|
A |
1.45 |
|
Γ1 |
0.0004 |
|
N |
0.032 |
|
C |
0.044 |
| D0 | 0.013 |
Here A is the activation rate of Ras ·GTP catalyzed by Cdc25; Γ1 is the affinity of both Cdc25 and Ira1/2 for Ras ·GTP; N is the reaction rate of Ira1/2; C is the production rate of cAMP due to the basal activity of adenylate cyclase; D0 represents the decay rate of cAMP in the absence of activated PDEs.
