Examples of therapeutic cargos and particle matrix components that may be mixed and processed into PRINT molds to produce monodisperse, shape-specific particles. (a) A pre-particle film (red) is married to PRINT molds (green) at elevated temperature followed by solidification after cooling to room temperature. (b) Pre-particle solution (red) is laminated into PRINT molds (green) followed by exposure to UV light for photochemical curing. (c) Protein (red sphere) contains primary amine residues that are reacted with a disulfide-containing bis(imidazole carboxylate) (DIC) crosslinker. (d) PLGA-siRNA NPs on harvesting layer of poly(vinyl alcohol) (PVA) (yellow) are collected in solution with cationic and endosomolytic lipids. (e) Lysine residues on hemoglobin are coupled to carboxylic acid-containing hydrogel microparticles through amidation. SEM micrographs illustrate the morphology of DIC-crosslinked BSA-Replicon microparticles (scale bar = 5 µm), lipid-coated, rod-shaped PLGA particles (scale bar = 2 µm), and gemcitabine prodrug PEG NPs (scale bar = 1 µm).19–20,22 Adapted with permission from the American Chemical Society. Copyright 2011 and 2012 American Chemical Society.