TABLE 4.

Membrane Serine Protease Inhibitors¹

	Endogenous Protein Inhibitors												Other Protein Inhibitors
Proteases2	Kunitz		Serpin3								Assay	Refs	SLPI4	SBTI5	Aprotinin	Leupeptin	Ecotin	Refs
	HAI-1	HAI-2	A1	A3	A5	C1	D1	E1	E2	F2
GPI Anchored
Prostasin	+	+	−	−					+		CA, GE	[85,205,234]		−	+	+		[15] [85]
Testisin															+	+		Upub6
Type I
Tryptase γ1			+								CA, GE	[26]	+/−		+	+		[26]
Type II
HAT													−	+	+	+		[54]
DESC1			−	−	+	+	−	+		+	CA,GE	[86,87,235]			+	+		[86,235]
HATL3															+	+		[102]
Hepsin	+	+	+/−			+		+		+	CA	[87,91,121]		+/−	+			[91,214]
TMPRSS13			−							+	CA	[84]		+	+	−		[84]
TMPRSS5																−		[220]
Enteropeptidase														+	+	+		[236,237]
Matriptase	+	+	+			+		+		+	CA, GE	[87,202] [238,239]		+	+	+	+	[240] [48]
Matriptase-2			−			+		+		+	CA	[87]			+	+		[104]
Matriptase-3	−				+	+	−	+		+	CA,GE	[203]			+	+		[203]
Polyserase-1			+							+	CA	[22]
Serase-1B			−			+/−		+		+	CA, GE	[23]	+	+/−	+	+		[23]
Corin														+/−	+	+		[228]

¹Inhibitory activity as assayed by catalytic assay (CA) or complex formation by gel electrophoresis (GE). (−) Inhibitory activity less than 10%; (+/−) Inhibitory activity less than 50%; (+) Inhibitory activity greater than 50%.

²Inhibitory profiles for HATL1/DESC3/TMPRSS11A, HATL2/DESC4, HATL4/TMPRSS11F, HATL5/TMPRSS11B, TMPRSS2, TMPRSS3, and TMPRSS4, are not known.

³Abbreviations: Serpins: A1, α1-proteinase inhibitor/α1-antitrypsin; A3, α1-antichymotrypsin; A5, protein C inhibitor (PCI); C1, antithrombin III; D1, heparin cofactor II; E1, plasminogen activator inhibitor-1 (PAI-1); E2, protease nexin 1; F2, α2-antiplasmin.

⁴SLPI, secretory leukocyte proteinase inhibitor

⁵SBTI, soybean Kunitz trypsin inhibitor

⁶published data, S. Netzel-Arnett