Figure 3. In vitro sibutramine administration increases the potency of NE-induced tension of epididymal cauda duct.

A: Concentration-response curves to NE in the absence and presence of increasing concentrations of sibutramine in the epididymal cauda. B: Concentration-response curves to methoxamine in the absence and presence of sibutramine 3 µM in the epididymal cauda. A–B: The data are expressed as the mean±SEM. Values of pEC₅₀ were different between NE curves, but not methoxamine curves (ANOVA, followed by Dunnett).