Figure 5. In vivo sibutramine administration decreases the tyramine-induced tension of epididymal cauda duct.
A: Concentration-response curves to norepinephrine in control and sibutramine-treated rats in the absence (open symbols) and in the presence (closed symbols) of cocaine 6 µM. B: Concentration-response curves to tyramine in control and sibutramine-treated rats before concentration-response curve to exogenous norepinephrine. C: Concentration-response curves to tyramine in control and sibutramine-treated rats after concentration-response curve to exogenous norepinephrine. A–C: The data are expressed as mean±SEM. Values of pEC50 were not different between curves (Student's t- test). D: Maximal response (Emax) to tyramine before and after concentration-response curve to norepinephrine (NE) between control and sibutramine-treated rats. The data are expressed as the mean±SEM. *p<0.05 vs control (Student's t- test).