Table 1. Comparisons of topological features of LMGs and HMGs.

	HPRD		LMGs		HMGs		Rank sum test
	Mean	Std	Mean	Std	Mean	Std	p-values
Degree	7.945	14.583	9.969	17.112	5.450	6.946	1.447e-5
Betweenness (*104)	2.914	12.221	3.897	14.671	1.303	2.823	5.0e-8
Closeness	0.241	0.031	0.248	0.030	0.231	0.030	7.06e-15