Table 3. Distributions of top 15 GO terms for the LMG and the HMG classes.
| GO code | GO term description | Appearances | P-value | |
| LMGs | HMGs | |||
| Over-represented in class LMG | ||||
| GO:0005634 | (CC) nucleus | 0.511 | 0.190 | <1.0e-32 |
| GO:0005737 | (CC) cytoplasm | 0.479 | 0.247 | 7.26e-12 |
| GO:0005515 | (MF) protein binding | 0.524 | 0.304 | 9.20e-11 |
| GO:0005654 | (CC) nucleoplasm | 0.131 | 0.036 | 1.67e-5 |
| GO:0005730 | (CC) nucleolus | 0.155 | 0.053 | 1.74e-5 |
| GO:0000166 | (MF) nucleotide binding | 0.200 | 0.089 | 2.67e-5 |
| GO:0003677 | (MF) DNA binding | 0.145 | 0.049 | 2.85e-5 |
| GO:0005829 | (CC) cytosol | 0.228 | 0.113 | 3.86e-5 |
| GO:0006355 | (BP) regulation of transcription, DNA-dependent | 0.130 | 0.049 | 2.37e-4 |
| GO:0005524 | (MF) ATP binding | 0.146 | 0.073 | 1.78e-3 |
| GO:0010467 | (BP) gene expression | 0.077 | 0.024 | 2.45e-3 |
| GO:0006915 | (BP) apoptotic process | 0.071 | 0.020 | 2.53e-3 |
| GO:0003700 | (MF) sequence-specific DNA binding transcription factor activity | 0.102 | 0.045 | 3.98e-3 |
| GO:0000122 | (BP) negative regulation of transcription from RNA polymerase II promoter | 0.064 | 0.024 | 1.28e-2 |
| GO:0045892 | (BP) negative regulation of transcription, DNA-dependent | 0.054 | 0.020 | 2.30e-2 |
| Over-represented in class HMG | ||||
| GO:0006935 | (BP) chemotaxis | 0.003 | 0.061 | <1.0e-32 |
| GO:0009897 | (CC) external side of plasma membrane | 0.005 | 0.069 | <1.0e-32 |
| GO:0006954 | (BP) inflammatory response | 0.011 | 0.109 | <1.0e-32 |
| GO:0006955 | (BP) immune response | 0.011 | 0.130 | <1.0e-32 |
| GO:0005615 | (CC) extracellular space | 0.031 | 0.247 | <1.0e-32 |
| GO:0005576 | (CC) extracellular region | 0.054 | 0.360 | <1.0e-32 |
| GO:0007267 | (BP) cell-cell signaling | 0.013 | 0.093 | 7.55e-15 |
| GO:0005887 | (CC) integral to plasma membrane | 0.042 | 0.146 | 1.74e-11 |
| GO:0007601 | (BP) visual perception | 0.005 | 0.040 | 2.94e-8 |
| GO:0007166 | (BP) cell surface receptor signaling pathway | 0.010 | 0.057 | 3.06e-8 |
| GO:0004872 | (MF) receptor activity | 0.058 | 0.146 | 3.42e-7 |
| GO:0008544 | (BP) epidermis development | 0.003 | 0.032 | 4.08e-7 |
| GO:0005102 | (MF) receptor binding | 0.012 | 0.057 | 7.08e-7 |
| GO:0005529 | (MF) sugar binding | 0.005 | 0.036 | 1.37e-6 |
| GO:0004888 | (MF) transmembrane signaling receptor activity | 0.003 | 0.028 | 1.49e-6 |
P values were calculated by using the chi-square statistic. Only top 15 terms significant at the 0.05 level are presented. Parenthesized markings stand for the three major sub-ontologies comprising GO: CC for “cellular component,” BP for “biological process,” and MF for “molecular function”.