Fig. 6.

Effect of ANG 1–7 with or without A-779 on SBP in Akita mice. A: longitudinal changes in mean SBP in male non-Akita WT mice (△), Akita mice (▲), Akita mice treated with ANG 1–7 (▽), and Akita mice treated with ANG 1–7 and A-779 (▼). Baseline SBP was measured daily over a 5-day period before initiation of treatment. B: cross-sectional analysis of SBP measured 2–3 times per animal per week in the morning without fasting, at the age of week 18 in non-Akita WT mice, Akita mice, Akita mice treated with ANG 1–7, and Akita mice treated with ANG 1–7 and A-779. Values are expressed as means ± SE (n = 6 per group). *P < 0.05; **P < 0.01; ***P < 0.005.