Fig. 11.

Pendrin gene ablation does not eliminate the fall in J_Cl observed with NO donor application. A and B: J_Cl and V_T were measured in CCDs from aldosterone-treated pendrin-null mice before and after the application of MAHMA (10 μM) to the bath. C and D: J_Cl and V_T were measured in CCDs from aldosterone-treated pendrin-null/Liddle's mice (Pds^−/−; L/L) before and after the application of MAHMA (10 μM) to the bath. Angiotensin II (10 nM) was present in the bath solution in all experiments. Solid lines show individual tubules. Dashed lines show individual experiments conducted in reverse order. Open squares show means ± SE.