Fig. 8.
NO donors reduce JCl through a thiazide-insensitive pathway. CCDs from aldosterone-treated wild-type mice were perfused in vitro. Throughout the experiments, hydrochlorothiazide (HCTZ; 100 μM) was present in the perfusate and angiotensin II (10 nM) was present in the bath. A and B: JCl and VT were measured before and after MAHMA application to the bath (10 μM). Solid lines show individual tubules. Dashed lines show individual experiments conducted in reverse order. Open squares show means ± SE.