Fig. 9.
NO targets the benzamil-sensitive component of JCl. CCDs from aldosterone-treated wild-type mice were perfused in vitro with benzamil (3 μM) in the perfusate. A and B: JCl and VT were measured in CCDs before and after MAHMA (10 μM) application to the bath. C and D: JCl and VT were measured before and after the application of l-NAME (100 μM) to the bath. Solid lines show individual tubules. Dashed lines show individual experiments conducted in the reverse order. Open squares show means ± SE. Angiotensin II (10 nM) was present in the bath solution in all experiments.