Figure 1.

Example of FOXO3-interaction network. Putative FOXO3 targets (orange nodes) as indicated by studies in mouse NSCs (Paik et al., 2009; Renault et al., 2009) with their first-degree neighbors (violet nodes) as inferred from the probabilistic functional network STRING. This corresponds to 255 FOXO3 targets that have 2689 first neighbors in STRING (confidence score greater than 0.7) out of the 374 putative targets initially identified by the Paik et al. and Renault et al. studies. The confidence score was set at 0.7 to ensure clarity of the graph. Biological content is illustrated in Figure S1.