Fig. 3.

A: mean ABP, integrated and raw lumbar SNA, and integrated and raw renal SNA of rats injected with control or anti-insulin affibodies at 10 min before an intracerebroventricular injection of insulin. In animals injected with the control affibody, intracerebroventricular injection of insulin significantly increased lumbar, but not renal, SNA. This lumbar sympathoexcitatory effect was attenuated in animals pretreated with ARC anti-insulin affibody. B: mean ± SE values of mean ABP, lumbar SNA, and renal SNA in both groups. Arrows denote ARC injection. *P < 0.05, control vs. anti-insulin affibody.