Table 1.

Changes in mean ABP and SNA after injection of control or anti-insulin affibody into the arcuate nucleus in Inactin-anesthetized rats that received an infusion of 0.45% NaCl (0.2–2.0 ml/h iv)

	Time
	−20 min	0 min	30 min	60 min	120 min
Control affibody
Mean ABP, mmHg	94 ± 3	93 ± 2	95 ± 4	94 ± 3	93 ± 2
Lumbar SNA, %	100 ± 1	101 ± 3	102 ± 3	104 ± 4	104 ± 6
Renal SNA, %	100 ± 1	99 ± 2	99 ± 4	98 ± 5	97 ± 5
Anti-insulin affibody
Mean ABP, mmHg	95 ± 2	94 ± 4	93 ± 4	92 ± 6	92 ± 5
Lumbar SNA, %	100 ± 1	100 ± 4	101 ± 6	102 ± 7	102 ± 6
Renal SNA, %	100 ± 1	100 ± 2	101 ± 4	102 ± 6	103 ± 7

Values are means ± SE; n = 3 animals injected with control affibody and 4 animals injected with anti-insulin affibody. ABP, arterial blood pressure; SNA, sympathetic nerve activity.