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. 2013 May 3;32(12):1665–1680. doi: 10.1038/emboj.2013.99

Figure 8.

Figure 8

Global function of PSF and CTBP1-AS governs androgen-dependent transcriptional program. (A) Detection of CTBP1-AS by RNA FISH and PSF immunofluorescence analysis. (B) Summary of androgen-repressed genes. The number of androgen-repressed genes with reduced repression after treatment with siPSF and/or siCTBP1-AS is indicated. (C) ChIP analysis (n=2) of AcH3 and PSF bindings in the vicinity of genes repressed by PSF and CTBP1-AS. Cells were transfected with siControl or siCTBP1-AS. Bar: s.d. *P<0.05, NS, P>0.05. (D) Working model of the role of CTBP1-AS and PSF in prostate cancer.