Fig. 1.

Functional hyperemia is compromised by high-fat diet (HFD). A: tracing of changes in cerebral blood flow (CBF) as measured by laser Doppler directed at 2 mm posterior and 5 mm lateral to bregma during whisker stimulation demonstrates that HFD blunts neurovascular coupling (n = 11/group). CD, control diet. B: quantitative analysis of total change (Δ) in CBF upon neuronal stimulation. C: K⁺-induced relaxations of parenchymal arterioles in brain slices are decreased in HFD-fed animals (n = 4/group). Values are means ± SE. *P < 0.05.