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Effect of HFD on basilar artery function after focal cerebral ischemia [middle cerebral artery occlusion (MCAO)]-reperfusion. HFD increased the contractile response to multiple agonists (A–C) and also reduced endothelium-dependent relaxation (D). Experimental values of contraction were calculated relative to the contractile response produced by 120 mM KCl, which was taken as 100% (n = 8/group). Values are means ± SE. *P < 0.05.
