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. 2013 Apr 12;304(12):H1680–H1696. doi: 10.1152/ajpheart.00070.2013

Fig. 11.

Fig. 11.

Response of L-type calcium current (ICa,L) in Epi and PM myocytes to changes in AP repolarization induced by intracellular acidosis (80.0 mM acetate). Control bathing solution was used for all experiments shown in this figure. A: ICa,L in control bathing solution was virtually the same in Epi (n = 11) and PM (n = 9) cells. B, a: example of an AP clamp experiment (Epi myocyte) showing the action of the intracellular acidosis template to decrease peak ICa,L and prolong its duration. b: Example of an AP clamp experiment (PM myocyte) showing the action of the intracellular acidosis template to prolong ICa,L duration with little effect on peak current. C: summary of results for peak ICa,L during AP clamps (Epi n = 11, PM n = 9; **P < 0.01, paired, control vs. acidosis template). D: summary of results for net Ca2+ influx via ICa,L during AP clamps. Same cells as in C. E: results in C and D expressed as % change. ##P < 0.01, unpaired, Epi vs. PM. CL = 2 s was used for all experiments shown in this figure.