Fig. 7.
Effect of acidosis on the time course of Ito recovery from inactivation. A: extracellular acidosis (pHo 6.5) had no significant effect on the time constant of recovery from inactivation (τcont = 986 ms, τacid = 1,009 ms; n = 4). a and b: Example signals from the same cell. c: Summarized results. B: in contrast, low pHi (80.0 mM acetate) slowed recovery from inactivation (τcont = 1,421 ms, τacid = 2,997 ms; n = 4). a and b: Example signals from the same cell. c: Summarized results. Clamp CL = 10 s. Insets: averaged actual values of Ito (pA/pF) in cells clamped with test pulses (P2) to +60 mV after conditioning clamp pulse (P1) to +60 mV.