Table 1.

Effect of acidosis and Cd²⁺ on I_to steady-state inactivation parameters

	200 mM Cd2+		No Cd2+
	Extracellular acidosis (n = 4)	Intracellular acidosis (n = 5)	Extracellular acidosis (n = 4)	Intracellular acidosis (n = 4)	No Na+, No Cd2+ Extracellular Acidosis (n = 5)
Control V1/2, mV	−34.6 ± 1.8	−34.3 ± 1.8	−44.4 ± 1.6	−38.6 ± 2.1	−43.5 ± 0.4
Acidosis V1/2, mV	−28.7 ± 1.6**	−34.4 ± 2.4	−34.5 ± 2.5**	−38.2 ± 1.6	−29.2 ± 1.4**
Control slope k	5.4 ± 0.3	5.7 ± 0.3	5.6 ± 0.7	4.4 ± 0.2	10.3 ± 0.5
Acidosis slope k	5.6 ± 0.2	7.1 ± 0.4	5.1 ± 0.4	5.3 ± 0.5	8.8 ± 0.4*

Values are mean ± SE half-maximal inactivation potential (V_1/2) and k determined from best fits of Boltzmann functions. I_to, transient outward current.

^*P < 0.05,

^**P < 0.01 vs. control, paired.