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. 2013 Jun 13;7:99. doi: 10.3389/fnins.2013.00099

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Copyright © 2013 Peluso.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Progesterone (P4)-PGRMC1 interactions. (A) Shows a ligand-binding analysis of ³H-P4 to partially purified PGRMC1-GFP fusion protein. Specific ³H-P4-binding decreased with the addition of non-radioactive P4. Hill plot analysis (inset) yielded a straight line with a slope of 1.08, indicting that ³H-P4 specifically bound to PGRMC1-GFP in a competitive and reversible manner (Data from Figure 6 from Peluso et al., 2008). The effect of PGRMC1 siRNA on SIGC proliferation (B) apoptosis (C) and the percentage of cells in the metaphase stage of the cell cycle (D). ^*Indicates a value that is significantly different (p < 0.05) from scramble control (∅).