Table 1.
Mean GCR rates (± standard deviation) calculated from ≥3 independent experiments and normalized to the rate (1.5±0.7×10−10 GCR events/generation) in the wild type strain with no insert at the PRB1 locus.
| Sequence inserted at the PRB1 locus | |||||
|---|---|---|---|---|---|
| Genotype | No insert | Chr IG4 | Chr XG4 | G-rich | Non-G-rich |
| Wild type | 1 | 1.2±0.5 | 1.4±0.5 | 1.2±0.2 | 1.3±0.6 |
| pif1-m2 | 76±8 | 200±20 | 210±10 | 70±30 | 60±20 |
| rrm3Δ | 6±5 | 12±6 | 9±4 | 3±1 | 3.2±0.9 |
| sgs1Δ | 16±5 | 12±8 | 19±8 | ND | ND |
| pif1-m2 rrm3Δ | 210±32 | 1500±500 | 1900±200 | 200±10 | 250±40 |
| pif1-m2 sgs1Δ | 20±80 | 190±35 | 200±50 | ND | ND |
ND, not determined.